FENZISHI：C25H18N6O

　　FENZILIANG：428.54

吉林快三 　　BENPINZHUYAOCHENGFENWEIEBEISHATAN，QIHUAXUEMINGCHENGWEI：2-DINGJI-3-[[LIN-1H-5-SIZUOJIBENJI]BIANJI]-1，3-ERDANZALUO[4.4]REN-1-XI-4-TONG。

　　【XINGZHUANG】BENPINWEIBAISEHUOLEIBAISEPIAN。

　　【YAOLIDULI】EBEISHATANSHIYIZHONGYOUXIAODE、KOUFUHUOXINGDEXUANZEXINGXUEGUANJINZHANGSU-IISHOUTI(AT1YAXING)JIEKANGJI。BUGUANXUEGUANJINZHANGSU-IIDELAIYUANHUOHECHENGTUJINGRUHE，TAYINGGAINENGZUDUANSUOYOUYOUAT1SHOUTIJIEDAODEXUEGUANJINZHANGSU-IIDEZUOYONG。QIDUIXUEGUANJINZHANGSU-IISHOUTI(AT1)XUANZEXINGJIEKANGZUOYONGDAOZHILEXUEJIANGSHENSUHEXUEGUANJINZHANGSU-IISHUIPINGDESHENGGAOHEXUEJIANGQUANGUTONGSHUIPINGDEJIANGDI。JIYUWUDIANJIEZHIWENLUANDEHUANZHEDANDUSHIYONGTUIJIANJILIANGDEEBEISHATANSHI，XUEQINGJIABUHUISHOUDAOMINGXIANYINGXIANG。EBEISHATANBUYIZHIXUEGUANJINZHANGSUZHUANHUANMEI(ACEHUOJIMEIII)，ZAIGAIMEIDEZUOYONGXIANENGSHENGCHENGXUEGUANJINZHANGSU-II，YENENGJIANGHUANJITAIJIANGJIEWEIFEIHUOXINGDAIXIEWU。EBEISHATANDEHUOXINGBUXUYAODAIXIEJIHUO。ZAISHIYONGYULINCHUANGXIANGGUANJILIANGSHIMEIYOUYICHANGDEJITIHUOBAQIGUANDUXINGZUOYONGDEZHENGJU。ZAILINCHUANGQIANANQUANXINGYANJIUZHONG，GAOJILIANG(SHUSHIYONGJILIANGWEI≥250mg/kg/RI;HENGHEHOUSHIYONGJILIANGWEI≥100mg/kg/RI)DEEBEISHATANDAOZHILEHONGXIBAOCANSHU(HONGXIBAOSHU，XUEHONGDANBAI，XUERONGBIJI)DEJIANSHAO。ZAIHENGAOJILIANGSHI(≥500mg/kg/RI)，EBEISHATANKEZAISHUHEHENGHEHOUZHONGYOUDAOSHENZANGBIANXINGZUOYONG(RUJIANZHIXINGSHENYAN，SHENXIAOGUANZHONGZHANG，XUEJIANGNIAOSUDANHEJIGANNONGDUDESHENGGAO)，BEIRENWEISHIJIFAYUGAIYAODEDIXUEYAXIAOYING，HOUZHEKENENGDAOZHISHENZANGGUANZHUBUZU。ERQIEEBEISHATANKEYOUDAOSHENXIAOQIUPANGQIDEZENGSHENG/FEIHOU(DANGSHUSHIYONGJILIANG≥90mg/kg/RI;HENGHEHOUSHIYONGJILIANGWEI≥10mg/kg/RI)。SUOYOUZHEIXIEGAIBIANBEIRENWEISHIYOUYUEBEISHATANDEYAOLIZUOYONGSUOZHI。JIUEBEISHATANZAIRENLEISHIYONGDEZHILIAOJILIANGERYAN，SHENXIAOQIUPANGQIXIBAODEZENGSHENG/FEIHOUYUQIWUGUAN。SHANGWUGAIYAOZHITUBIAN、CUYOUSIFENLIEHEZHIAIDEZHENGJU。EBEISHATANDEDONGWUYANJIUXIANSHIQIDUISHUPEITAIDUANZANDEDUXINGXIAOYING(SHENYUCHENGQIANGZENGJIA，SHUNIAOGUANHUOPIXIASHUIZHONG)，CHUSHENGHOUJIUXIAOCHU。ZAITUZISHIYANZHONG，SHIYONGNENGMINGXIANYINQICIXINGDUXINGZUOYONGDEJILIANGSHIKEGUANCHADAOLIUCHANHUOZAOQIXISHOU。ZAISHUHETUZISHIYANZHONGMEIYOUGUANCHADAOZHIJIXIAOYING。

　　【YAODAIDONGLIXUE】KOUFUJIYAOHOU，EBEISHATANXISHOULIANGHAO;QIJUEDUISHENGWULIYONGDUDAYUEWEI60-80%。JINSHIBUHUIMINGXIANYINGXIANGQISHENGWULIYONGDU。EBEISHATANXUEJIANGDANBAIDEJIEHELVDAYUEWEI96%，JIHUBUHEXUEYEXIBAOJIEHE，QIFENBURONGJIWEI53-93SHENG。KOUFUHUOJINGMAIJIYU14CEBEISHATANHOU，XUEYEXUNHUANNEI80-85%DEFANGSHEXINGLAIZIYUANXINGDEEBEISHATAN。EBEISHATANZAIGANZANGYUPUTAOTANGQUANSUANJIEHEYANGHUAERBEIDAIXIE。ZHUYAODEXUNHUANDAIXIEWUWEIPUTAOTANGQUANSUANJIEHEXINGEBEISHATAN(DAYUE6%)。TIWAISHIYANXIANSHIEBEISHATANZHUYAOYOUXIBAOSESUP450MEICYP2C9YANGHUADAIXIE，TONGGONGMEICYP3A4JIHUMEIYOUXIAOYING。EBEISHATANDEYAODAIDONGLIXUEZAI10-600mgFANWEINEIXIANSHIXIANXINGHEJILIANGXIANGGUANXING。DANGKOUFUJILIANGDAYU600mg(LIANGBEIDEZUIDATUIJIANJILIANG)SHI，KEGUANCHADAOQIBUNENGANBILIDIZENGJIA;QIJILISHANGBUMINGQUE。KOUFUHOUDAYUE1.5-2XIAOSHIKEDAXUEJIANGFENGNONGDU。JITIZONGQINGCHULVHESHENQINGCHUFENBIEWEI157-176HE3.0-3.5ml/min，EBEISHATANDEZHONGMOQINGCHUBANSHUAIQIWEI11-15XIAOSHI。ANMEIRIYICIDEFUYAOFANGFA，SANTIANNEIDADAOXUEJIANGWENTAINONGDU。ZHONGFUMEIRIYICIJIYAOHOUXUEJIANGNEIJIXUYOUXIAN(<20%)。ZAIMOUGEYANJIUZHONGGUANCHADAONVXINGGAOXUEYAHUANZHEEBEISHATANDENONGDUJIAOGAO。RANER，QIBANSHUAIQIHEJIXUMEIYOUCHAYI。NVXINGHUANZHEBUXUYAOWUJILIANGDIAOZHENG。EBEISHATANDECmaxHEAUCZHIZAILAONIANSHOUSHIZHE(≥65SUI)BINEIXIENIANQINGSHOUSHIZHE(18-40SUI)GAO。RANERZHONGMOBANSHUAIQIMEIYOUMINGXIANGAIBIAN。LAONIANHUANZHEYEBUXUYAODIAOZHENGJILIANG。EBEISHATANJIQIDAIXIECHANWUYOUDANDAOHESHENZANGPAIXIE。KOUFUHUOJINGMAIJIYU14CEBEISHATANHOU，DAYUE20%DEFANGSHEXINGKEZAINIAOYEZHONGHUISHOU，QIYUPAIXIEZAIFENBIANZHONG。BUZU2%DEJILIANGYIYUANXINGZAINIAOYEZHONGPAIXIE。SHENGONGNENGSUNHAI：SHENGONGNENGSUNHAIDEHUANZHEHUONEIXIEJINXINGXUEYETOUXIDEHUANZHE，EBEISHATANDEYAODAIDONGLIXUECANSHUMEIYOUMINGXIANGAIBIAN。EBEISHATANBUNENGJINGXUEYETOUXIQINGCHU。GANGONGNENGSUNHAI：DUIQINGDUZHIZHONGDUGANYINGHUADEHUANZHE，EBEISHATANDEYAODAIDONGLIXUECANSHUMEIYOUMINGXIANGAIBIAN。DUIYANZHONGGANGONGNENGSUNHAIDEHUANZHEMEIYOUJINXINGYAODAIDONGLIXUEDEYANJIU。

吉林快三 　　【YONGFAYONGLIANG】TONGCHANGJIANYIDECHUSHIJILIANGHEWEICHIJILIANGWEIMEIRI0.15g(ERPIAN)，YINSHIDUIFUYAOWUYINGXIANG。YIBANQINGKUANGXIA，EBEISHATAN0.15gMEITIANYICIBI75mg(YIPIAN)NENGGENGHAODIKONGZHI24XIAOSHIDEXUEYA。DANDUIMOUXIETESHUDEBINGREN，TEBIESHIJINXINGXUEYETOUXIHENIANLINGCHAOGUO75SUIDEBINGREN，CHUSHIJILIANGKEKAOLVYONG75mg。SHIYONGEBEISHATAN0.15gMEITIANYICIBUNENGYOUXIAOKONGZHIXUEYADEHUANZHE，KEJIANGBENPINJILIANGZENGZHI0.30g(SIPIAN)，HUOZHEZENGJIAQITAKANGGAOXUEYAYAOWU。YOUQISHIJIAYONGSHUANGQINGKENIAOSAILEILINIAOJIYIJINGXIANSHICHUJUYOUFUJIAXIAOYING。ZAIHUANYOU2XINGTANGNIAOBINGDEGAOXUEYAHUANZHEZHONG，ZHILIAOCHUSHIJILIANGYINGWEI0.15gMEIRIYICI，BINGKEZENGLIANGZHI0.30gMEIRIYICI，ZUOWEIZHILIAOSHENZANGJIBINGJIAOHAODEWEICHIJILIANG。SHIYONGBENPINZHILIAOHUANYOU2XINGTANGNIAOBINGDEGAOXUEYAHUANZHEXIANSHICHUBENPINSHIHUANZHESHENZANGSHOUYI，ZHEIXIEJIEGUOSHIJIYUXUYAOBENPINHEQITAKANGGAOXUEYAYAOWUHEYONGLAIDADAOMUBIAOXUEYADEYANJIU。SHENGONGNENGSUNSHANG：SHENGONGNENGSUNSHANGDEHUANZHEWUXUDIAOZHENGBENPINJILIANG，DANDUIJINXINGXUEYETOUXIDEBINGREN，CHUSHIJILIANGKEKAOLVSHIYONGDIJILIANG(75mg)。XUERONGLIANGXIAOHAO：XUERONGLIANGHE/HUONAXIAOHAODEHUANZHEZAISHIYONGBENPINQIANYINGJIUZHENG。GANGONGNENGSUNHAI：QINGZHONGDUGANGONGNENGSUNHAIDEHUANZHEWUXUDIAOZHENGBENPINJILIANG。DUIYANZHONGGANGONGNENGSUNHAIDEBINGREN，MUQIANWULINCHUANGJINGYAN。

　　【BULIANGFANYING】ZAIJIESHOUBENPINZHILIAODEHUANZHEZHONGCHUXIANDEBULIANGFANYINGZONGTISHANGSHIQINGDUHEZANSHIDE。

　　GAOXUEYAHUANZHE：ZAISHIYONGBENPINDEANWEIJIDUIZHAOZHILIAOGAOXUEYAHUANZHEDELINCHUANGSHIYANZHONG，BULIANGFANYINGZONGDEFASHENGLVZAIBENPINZHILIAOZUHEANWEIJIZUZHONGWUCHAYI。YOUYURENHELINCHUANGHESHIYANYICHANGSHIJIANERDAOZHIZHILIAOZHONGDUANDESHIJIAN，ZHILIAOZUSHAOYUANWEIJIZU。BULIANGFANYINGDEFASHENGLVHEJILIANG(ZAITUIJIANJILIANGFANWEINEI)、XINGBIE、NIANLING、ZHONGZUHUOZHILIAOSHIJIANWUGUAN。BUGUANSHIFOUYUZHILIAOYOUGUAN，BENPINANWEIJIDUIZHAOLINCHUANGSHIYANZHONG，ZHILIAOZUZHONGGAOXUEYAHUANZHEBULIANGFANYINGSHIJIANFASHENGLVDAYUDENGYU1%DEBULIANGFANYINGSHIJIAN。CHUTOUTONG、JIROUGUGESUNSHANGHECHAOHONGWAI，EBEISHATANHEANWEIJIZUQITABULIANGSHIJIANFASHENGLVXIANGSI。ANWEIJIZUTOUTONGFASHENGLVMINGXIANGAOYUEBEISHATANZU，FASHENGJIROUGUGESUNSHANGQINGKUANGEBEISHATANZUMINGXIANGAOYUANWEIJIZU，DANSHIYANGUANCHAZHERENWEISUOYOUBAOGAODEJIROUGUGESUNSHANGYUFUYONGEBEISHATANWUGUAN。0.6%FUYONGEBEISHATANDEBINGRENFASHENGCHAOHONG，ERFUYONGANWEIJIDEBINGRENWEIFASHENGCHAOHONG。CHAOHONGFASHENGLVYUJILIANGWUGUAN，QIEBUYUQITABULIANGSHIJIANXIANGBANFASHENG，MUQIANSHANGBUZHIFASHENGCIZHENGZHUANGSHIFOUYUEBEISHATANXIANGGUAN。

　　BANYOUSHENZANGJIBINGDEGAOXUEYAHE2XINGTANGNIAOBINGHUANZHE：ZAIYIXIANGANWEIJIDUIZHAODELINCHUANGSHIYAN(IRMA2)ZHONG，QIZHONGBAOKUO590WEIHUANYOUGAOXUEYA、2XINGTANGNIAOBING、WEILIANGBAIDANBAINIAOHESHENGONGNENGZHENGCHANGDESHOUSHIZHE，QIBAODAODEHEBENPINZUIYOUGUANDEBULIANGFANYINGWEITOUYUN、TIWEIXINGTOUYUNHETIWEIXINGDIXUEYA。EBEISHATAN300mgZHILIAOZUZHONG，TOUYUNDEFASHENGLVWEI2.5%，ERTIWEIXINGXUANYUNHETIWEIXINGDIXUEYAJUNWEI0.5%。MEIYOUYOUYUZHEIXIEBULIANGFANYINGERTINGZHIZHILIAODEBAODAO。ZAILINGYIXIANGANWEIJIDUIZHAODELINCHUANGSHIYAN(IDNT)ZHONG，QIZHONGBAOKUO1715WEIHUANYOUGAOXUEYA、2XINGTANGNIAOBING、DANBAINIAO≥900mg/RIHERIXUEQINGJIGANZAI1.0-3.0mg/dlFANWEIDESHOUSHIZHE，CHULETIWEIXINGXUANYUN，QITABULIANGFANYINGHEZAIMEIYOUHEBINGZHENGDEGAOXUEYAHUANZHEZHONGSUOBAODAODEXIANGLEISI。ZAIGAILINCHUANGSHIYANZHONG，EBEISHATANZUZHONGTIWEIXINGXUANYUNDEFASHENGLVGAOYUANWEIJIZU;TOUYUNDEFASHENGLVZAIEBEISHATANZUHEANWEIJIZUFENBIEWEI10.2%HE6.0%;ERTIWEIXINGXUANYUNDEFASHENGLVZAIEBEISHATANZUHEANWEIJIZUFENBIEWEI5.4%HE2.7%;TIWEIXINGDIXUEYADEFASHENGLVZAIEBEISHATANZUHEANWEIJIZUFENBIEWEI5.4%HE3.2%。ZAIGAILINCHUANGSHIYANZHONG，YOUYUTIWEIXINGZHENGZHUANGERTINGZHIZHILIAO。QIZHONGTOUYUNZAIEBEISHATANZUHEANWEIJIZUFENBIEWEI0.3%HE0.5%;TIWEIXINGXUANYUNDEFASHENGLVZAIEBEISHATANZUHEANWEIJIZUFENBIEWEI0.2%HE0.0%。MEIYOUHUANZHEYOUYUTIWEIXINGDIXUEYAERTINGZHIZHILIAO。

吉林快三 　　SHIYANSHIJIANYANCANSHU：GAOXUEYA：JINGUANXUEJIANGJISUANJIMEIDEMINGXIANZENGGAOZAIEBEISHATANZHILIAOZUZHONGFASHENGLVGAOYUANWEIJIZU(ZHILIAOZUHEANWEIJIZUFENBIEWEI1.7%HE0.7%)，DANMEIYOUYILIHUANZHEYOUYUBEIFENLEIWEIYANZHONGBULIANGSHIJIANERDAOZHIYAOWUZHILIAOZHONGDUANHUOZHEBEIRENWEIYUKEJIANDINGDELINCHUANGJIROUGUGESHIJIANYOUGUAN。DANGSHENGONGNENGZHENGCHANGDEYUANFAXINGGAOXUEYAHUANZHEJIESHOUBENPINZHILIAOSHI，BUXUYAOJINXINGTESHUDESHIYANSHICANSHUDEJIANCE。

　　BANYOU2XINGTANGNIAOBINGHESHENZANGJIBINGDEGAOXUEYAHUANZHE：ZAIDUIBANYOUTANGNIAOBINGSHENBINGHUANZHEJINXINGDELINCHUANGSHIYANZHONG，CHULEGAOJIAXUEZHENG，QITADESHIYANSHICANSHUHEDANCHUNGAOXUEYADECANSHULEISI。ZAIYIXIANGANWEIJIDUIZHAODELINCHUANGSHIYAN(IRMA2)ZHONG，QIZHONGBAOKUO590WEIHUANYOUGAOXUEYA、2XINGTANGNIAOBING、WEILIANGBAIDANBAINIAOHESHENGONGNENGZHENGCHANGDESHOUSHIZHE，QIBAODAODE≥5.5mEq/LDEGAOJIAXUEZHENGDEFASHENGLVZAIEBEISHATAN300mgZUHEANWEIJIZUFENBIEWEI29.4%HE22%;EBEISHATANZHILIAOZUZHONG，YOUYUGAOJIAXUEZHENGERTINGZHIZHILIAODEFASHENGLVWEI0.5%。ZAILINGYIXIANGANWEIJIDUIZHAODELINCHUANGSHIYAN(IDNT)ZHONG，QIZHONGBAOKUO1715WEIHUANYOUGAOXUEYA、2XINGTANGNIAOBING、DANBAINIAO≥900mg/RIHEXUEQINGJIGANZAI1.0-3.0mg/dlFANWEIDESHOUSHIZHE，QIBAODAODE≥5.5mEq/LDEGAOJIAXUEZHENGDEFASHENGLVZAIEBEISHATANZUHEANWEIJIZUFENBIEWEI46.3%HE26.3%;EBEISHATANZHILIAOZUZHONG，YOUYUGAOJIAXUEZHENGERTINGZHIZHILIAODEFASHENGLVZAIEBEISHATANZUHEANWEIJIZUFENBIEWEI2.1%HE0.4%。

　　SHANGSHIHOUJINGYAN：JIURUQITAXUEGUANJINZHANGSUIISHOUTIJIEKANGJI，HANYOUGUOMINFANYING(PIZHEN，QIANMAZHEN，XUEGUANXINGSHUIZHONG)DEBAODAO。EBEISHATANZHILIAOZUHANYOUKESOUBAODAO。ZAISHANGSHIHOUJIANCEZHONGHANYOUBAODAODEBULIANGFANYING：DAIXIEHEYINGYANGSHIDIAO：GAOJIAXUEZHENG;SHENJINGXITONGGONGNENGWENLUAN：TOUYUN，TOUTONG;ERHEMILUYICHANG：ERMING;XINZANGYICHANG：XINDONGGUOSU;WEICHANGDAOYICHANG：FUXIE，XIAOHUABULIANG，EXIN;GANDANYICHANG：GANGONGNENGYICHANG，GANYAN;GUGEJI、JIEDIZUZHIHEGUGEYICHANG：JIROUTONGHEGUANJIETONG;SHENZANGHEMINIAODAOYICHANG：SHENGONGNENGSUNHAIBAOKUOSHENGONGNENGSHUAIJIEDEGELI;QUANSHENYICHANGHEJIYAOBUWEIQINGKUANG：XURUO。

　　【JINJI】YIZHIDUIBENCHENGFENGUOMIN。HUAIYUNDEDI4ZHIDI9GEYUE。BURUQI。

　　【ZHUYISHIXIANG】RONGLIANGSUNHAOHUANZHE：DUIYUFUYONGQIANGXIAOLINIAOJI，YINSHIZHONGYANGEXIANYANYIJIFUXIEOUTUERSHIXUERONGLIANGBUZUDEHUANZHE，ZAIFUYONGBENPINSHIKENENGHUIFASHENGZHENGZHUANGXINGDIXUEYA，TEBIESHISHOUCIFUYONGSHIGENGRONGYIFASHENG。ZAIKAISHIFUYONGBENPINZHIQIANYINGJIUZHENGZHEIXIEQINGKUANG。

吉林快三 　　SHENXUEGUANXINGGAOXUEYA：CUNZAISHUANGCESHENDONGMAIXIAZHAIHUODANGEGONGNENGSHENDEDONGMAIFASHENGXIAZHAIDEHUANZHE，SHIYONGYINGXIANGSHENSU-XUEGUANJINZHANGSU-QUANGUTONGXITONGDEYAOWUSHI，FASHENGYANZHONGDIXUEYAHESHENGONGNENGBUQUANDEWEIXIANZENGJIA。JINGUANBENPINDEYANJIUZHONGMEIYOUFAXIANZHEIZHONGQINGKUANG，DANSHIYONGSHIYINGKAOLVXUEGUANJINZHANGSUIISHOUTIJIEKANGJIDELEISIXIAOYING。SHENGONGNENGSUNHAIHESHENZANGYIZHI：DANGSHENGONGNENGSUNHAIDEHUANZHESHIYONGBENPINSHI，TUIJIANDUIXUEQINGJIAHEJIGANYINGDINGQIJIANCE。MEIYOUGUANYUJINQIJINXINGSHENYIZHIHUANZHESHIYONGBENPINDEJINGYAN。

　　HEBINGYOU2XINGTANGNIAOBINGHESHENZANGJIBINGDEGAOXUEYAHUANZHE：ZAISUOYOUDEYAZUZHONG，DUIWANQISHENZANGJIBINGHUANZHEYANJIUJIEGUOJINXINGFENXIXIANSHIEBEISHATANDUISHENZANGHEXINXUEGUANSHIJIANDEXIAOYINGSHIBUYIZHIDE。YOUQISHIBENPINSIHUDUIFUNVHEFEIBAIZHONGRENQUNSHOUYIJIAOSHAO。

　　GAOJIAXUEZHENG：JIURUQITAYINGXIANGSHENSU-XUEGUANJINZHANGSU-QUANGUTONGXITONGDEYAOWU，SHIYONGBENPINGUOCHENGZHONGKENENGHUIFASHENGGAOJIAXUEZHENG，YOUQISHICUNZAISHENGONGNENGSUNHAI、YOUYUTANGNIAOBINGSHENSUNHAISUOZHIDEMINGXIANDANBAINIAOHE/HUOXINLISHUAIJIE。JIANYIMIQIEJIANCEZHEIXIEHUANZHEDEXUEQINGJIASHUIPING。

　　LIJI：BUJIANYIBENPINHELIJIHEYONG。

　　ZHUDONGMAIHEERJIANBANXIAZHAI，FEIHOUGENGZUXINGXINJIBING：JIURUSHIYONGQITADEXUEGUANKUOZHANGJI，ZHUDONGMAIHEERJIANBANXIAZHAIJIFEIHOUGENGZUXINGXINJIBINGHUANZHESHIYONGBENPINSHIYINGJINSHEN。

吉林快三 　　YUANFAXINGQUANGUTONGZENGDUOZHENG：YUANFAXINGQUANGUTONGZENGDUOZHENGDEHUANZHETONGCHANGDUINEIXIETONGGUOYIZHISHENSU-XUEGUANJINZHANGSUXITONGDEKANGGAOXUEYAYAOWUMEIYOUFANYING。YINCIBUTUIJIANZHEIXIEHUANZHESHIYONGBENPIN。

吉林快三 　　YIBANZHUYISHIXIANG：DUIYUNEIXIEXUEGUANZHANGLIHESHENGONGNENGZHUYAOYILAISHENSU-XUEGUANJINZHANGSU-QUANGUTONGXITONGHUOXINGDEHUANZHE(RUYANZHONGCHONGXUEXINGXINLISHUAIJIEHUANZHEHUOZHESHENZANGJIBINGHUANZHEBAOKUOSHENDONGMAIXIAZHAI)，SHIYONGNENGYINGXIANGGAIXITONGDEXUEGUANJINZHANGSUZHUANHUANMEIYIZHIJIHUOXUEGUANJINZHANGSUIISHOUTIJIEKANGJIZHILIAOSHI，YUCHUXIANJIXINGDIXUEYA、DANZHIXUEZHENG、SHAONIAO、HUOSHAOJIANDEJIXINGSHENGONGNENGSHUAIJIEYOUGUAN。JIURUSHIYONGRENHEKANGGAOXUEYAYAOWU，DUIQUEXUEXINGXINJIBINGHUOQUEXUEXINGXINXUEGUANJIBINGHUANZHEGUODUJIANGXUEYAKENENGDAOZHIXINJIGENGSIHUOZHONGFENG。RUTONGXUEGUANJINZHANGSUZHUANHUANMEIYIZHIJISUOGUANCHADEJIEGUO，EBEISHATANHEQITAXUEGUANJINZHANGSUJIEKANGJIZAIJIANGDIXUEYAFANGMIAN，DUIHEIZHONGRENQUNDELIAOXIAOMINGXIANCHAYUFEIHEIZHONGRENQUN。KENENGYOUYUHEIZHONGRENQUNDEGAOXUEYAHUANZHEZHONGDISHENSUSHUIPINGBILIJIAOGAO。

吉林快三 　　【YUNFUJIBURUQIFUNVYONGYAO】RENSHEN：ZUOWEIBAOXIANCUOSHI，ZAIRENSHENDEQIANSANYUEZUIHAOBUSHIYONGBENPIN。ZAIJIHUARENSHENQIANYINGZHUANHUANWEIHESHIDETIDAIZHILIAO。ZAIRENSHENDEDI4YUEZHIDI9YUE，ZHIJIEZUOYONGYUSHENSU-XUEGUANJINZHANGSUXITONGDEWUZHINENGYINQITAIERHEXINSHENGERDESHENGONGNENGSHUAIJIE，TAIERTOULUFAYUBULIANGHETAIERSIWANG，YINCI，BENPINJINYONGYURENSHEN4YUEZHI9YUEDEYUNFU。RUGUOBEICHACHUHUAIYUN，YINGJINKUAITINGYONGBENPIN，RUGUOYOUYUSHUHUZHILIAOLEJIAOZHANGSHIJIAN，YINGCHAOSHENGJIANCHATOULUHESHENGONGNENG。

　　MIRU：BENPINJINYONGYUBURUQI。EBEISHATANSHIFOUFENMIRURENRUZHIZHONGSHANGBUQINGCHU。EBEISHATANNENGFENMIRUSHUDERUZHIZHONG。

　　【ERTONGYONGYAO】MUQIANWUERTONGFUYONGBENPINANQUANXINGHEYOUXIAOXINGDEYANJIUZILIAO。

　　【LAONIANHUANZHEYONGYAO】SUIRANJIANYICHAOGUO75SUIDEBINGRENCHUSHIZHILIAOJILIANGYONG75mg，DANDUILAONIANHUANZHETONGCHANGWUXUDIAOZHENGJILIANG。

吉林快三 　　【YAOWUXIANGHUZUOYONG】LINIAOJIHEQITAKANGGAOXUEYAYAOWU：DANGBENPINHEQITAJIANGXUEYAYAOWUHEYONGSHI，QIJIANGXUEYAXIAOYINGKENENGZENGQIANG。RANER，BENPINKEHEQITAJIANGXUEYAYAOWURUZHANGXIAOGAITONGDAOZUDUANJI、βSHOUTIZUDUANJIHESAIQINLEILINIAOJIANQUANDIHEYONG。DANGSHOUCISHIYONGBENPINZHIQIANYIYONGGUOGAOJILIANGLINIAOJIKENENGDAOZHIRONGLIANGXIAOHAOHEDIXUEYADEFENGXIAN。

　　BUJIAYAOWUHEBAOJIALINIAOJI：JIYUQITANENGYINGXIANGSHENSU-XUEGUANJINZHANGSUXITONGDEYAOWUDELINCHUANGSHIYONGJINGYAN，HEYONGBAOJIALINIAOJI、BUCHONGJIA、HANJIADEYANTIDAIWUHUOZHEQITANENGZENGJIAXUEQINGJIASHUIPING(LIRUGANSUNA)DEYAOWUKEYIDAOZHIXUEQINGJIADEZENGGAO，YINCIBUJIANYIHEYONG。

　　LIJI：DANGLIJIHEXUEGUANJINZHANGSUZHUANHUANMEIYIZHIJIHEYONGSHI，YOUBAODAOXUEQINGLIKENIXINGSHENGGAOHECHUXIANDUXINGZUOYONG。ERQIESAIQINLEILINIAOJIKEJIANSHAOSHENZANGDUILIDEQINGCHU，LEISIDEXIAOYINGZAIBENPINDESHIYONGZHONGHANYOUBAODAO。YINCIBUTUIJIANHEBINGSHIYONG(4.4)。RUGUOBENPINXUYAOHELIJIHEYONGSHI，TUIJIANDUIXUEQINGLINONGDUJINXINGZIXIJIANCE。

吉林快三 　　YOUGUANYAOWUXIANGHUZUOYONGDEQITAXINXI：ZAIJIANKANGNANXINGSHOUSHIZHEZHONG，DANGHEEBEISHATAN150mgHEYONGSHI，DIGAOXINDEYAODAIDONGLIXUEMEIYOUGAIBIAN。DANGHESHUANGQINGKENIAOSAIHEYONGSHI，EBEISHATANYAODAIDONGLIXUEMEIYOUSHOUYINGXIANG。EBEISHATANZHUYAOYOUCYP2C9DAIXIE，JIAOSHAOBUFENTONGGUOPUTAOTANGQUANSUANHUADAIXIE。YIZHIPUTAOTANGQUANSUANZHUANYIMEITUJINGBUHUIDAOZHILINCHUANGYIYIDEXIANGHUZUOYONG。ZAITIWAISHIYANZHONG，KEGUANCHADAOEBEISHATANHEHUAFALIN、JIABENHUANGDINGNIAO(CYP2C9DIWU)HENIFEIDIPING(CYP2C9YIZHIJI)ZHIJIANDEXIANGHUZUOYONG。RANERZAIJIANKANGNANXINGSHOUSHIZHEZHONG，DANGEBEISHATANHEHUAFALINHEYONGSHIMEIYOUGUANCHADAOYOUYIYIDEYAODAIDONGLIXUEHEYAOXIAODONGLIXUEDEXIANGHUYINGXIANG。DANGHENIFEIDIPINGHEYONGSHI，EBEISHATANDEYAODAIDONGLIXUEBUSHOUYINGXIANG。CYP2C9YOUDAOJIRULIFUPINGDUIEBEISHATANYAODAIDONGLIXUEDEYINGXIANGMEIYOUXIANGGUANYANJIU。JIYUTIWAISHIYANZILIAO，HENEIXIEDAIXIEYIKAOXIBAOSESUP450TONGGONGMEICYP1A1、CYP1A2、CYP2A6、CYP2B6、CYP2D6、CYP2E1HUOCYP3A4DEYAOWUBUHUIFASHENGXIANGHUZUOYONG。

吉林快三 　　【YAOWUGUOLIANG】CHENGNIANRENBENPINJILIANGDA900mg/RI，LIANXU8ZHOUJIYAOMEIYOUXIANSHIDUXING。EBEISHATANGUOLIANGZUIKENENGDEBIAOXIANWEIDIXUEYAHEXINDONGGUOSU;YEHUIFASHENGXINDONGGUOHUAN。BENPINGUOLIANGDEZHILIAOWUXIANGGUANDETESHUZILIAO。YINGDUIHUANZHEYANMIJIANCE，ZHILIAOYINGGAISHIZONGTIHEZHICHIXINGDE。JIANYIDECUOSHIBAOKUOCUITUHE/HUOXIWEI。HUOXINGTANDUIYAOWUGUOLIANGZHILIAOYOUYONG。XUEYETOUXIBUNENGQINGCHUEBEISHATAN。

　　【GUIGE】75mg

吉林快三 　　【ZHUCUN】MIFENG，ZAIYINLIANGGANZAOCHUBAOCUN。

　　【BAOZHUANG】LVSUPAOZHAOBAOZHUANG，10PIAN/BAN，2BAN/HE。

吉林快三 　　【YOUXIAOQI】ZANDING18GEYUE。

　　【PIZHUNWENHAO】GUOYAOZHUNZIH20060794